Pfizer-BioNTech pushing 3-dose COVID-19 vaccination to fight omicron variant

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Pfizer and BioNTech say a three-shot course of their COVID-19 vaccine was able to neutralize the new omicron variant in a laboratory test, and that they could deliver an omicron-based vaccine in March 2022 if needed.

In the first official statement from vaccine manufacturers on the likely efficacy of their shot against the latest variant of concern, the companies said on Wednesday that two vaccine doses resulted in significantly lower neutralizing antibodies, but that a third dose of their vaccine increased the neutralizing antibodies by a factor of 25.

Blood obtained from people that had their third booster shot a month ago neutralized the omicron variant about as effectively as blood after two doses fought off the original virus first identified in China.

“Ensuring as many people as possible are fully vaccinated with the first two-dose series and a booster remains the best course of action to prevent the spread of COVID-19,” Pfizer boss Albert Bourla said in the statement.

In a later briefing, the companies stressed their findings are “preliminary,” with more research and real-world effectiveness data needed to inform the best path forward.

Though the necessity of additional boosters remains unclear, the companies said they would continue their effort to bring an omicron-specific COVID-19 vaccine to market, which they kick-started when the new lineage first raised global concern among scientists on Nov. 25.

A planned output of four billion doses of their vaccine in 2022 was not expected to change if an adapted vaccine was required, they added.

Optimism regarding protection against severe disease

The findings are broadly in line with a preliminary study published by researchers at the Africa Health Research Institute in South Africa on Tuesday, saying that omicron can partially evade protection from two doses of the Pfizer-BioNTech vaccine, suggesting also that a third shot might help fend off infection.

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A lab analysis at the university hospital of Frankfurt, however, found a reduced antibody response to omicron even after three shots.

The U.S.-German vaccine partners also struck an optimistic tone on the prospect of their shot protecting against any severe disease from omicron, even though the lab data did not yield new insights on that.

The vast majority of surface structures on the omicron spike protein targeted by the T-cells, which typically emerge after vaccination, are not affected by omicron’s mutations, they said.

“The companies believe that vaccinated individuals may still be protected against severe forms of the disease,” they added.

T-cells are the second pillar of an immune response, alongside antibodies, and are believed to prevent severe disease by attacking infected human cells.

So far, the omicron variant has been reported in 57 countries and the number of patients needing hospitalisation is likely to rise as it spreads, though the level of disease severity it causes is still unclear, the World Health Organization said on Wednesday.

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